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Therapeutic vaccine candidates using viral vectors encoding LMP2 have efficiently induced virus-one of a kind CD8⁺ T mobile responses in early-part medical trials.
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Therapeutic vaccine candidates applying viral vectors encoding LMP2 have correctly induced virus-distinct CD8⁺ T mobile responses in early-stage scientific trials. Moreover, adoptive T cell therapies like posoleucel also target LMP2 together with other latency proteins for example EBNA1, reinforcing its importance being a conserved and immunodominant antigen.
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Among the these latency proteins, EBNA-3a performs a supportive but non-important position in B mobile transformation: EBV mutants missing EBNA-3a can nevertheless remodel B cells, but with significantly minimized performance.
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